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Peer-Reviewed Evidence

The Science Behind Clinical Hypnosis

Explore 23 peer-reviewed studies from leading medical journals demonstrating the effectiveness of hypnotherapy.

40+
Years of Gut Research
23
Studies Cited
2,000+
IBS Patients Studied
76%
Average Improvement

Gut-Directed Hypnotherapy

10 studies

70-80% of IBS patients see significant improvement

70%
Response Rate
Whorwell et al. (1984)

Manchester Protocol - pioneering gut hypnotherapy

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76%
IBS Improvement
Ford et al. (2019)

Systematic review: 8 RCTs, 464 patients

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=
Equals FODMAP
Peters et al. (2016)

Hypnotherapy as effective as low FODMAP diet

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1yr+
Lasting Results
Lindfors et al. (2012)

138 refractory IBS patients - long-term benefits

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5
Sessions Only
Roberts et al. (2006)

Primary care RCT - brief intervention works

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80%
Long-term Success
Palsson et al. (2002)

7-year follow-up shows lasting results

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54%
Remission Rate
Moser et al. (2013)

Austrian IBS study - 12-month follow-up

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244
Patients
Nerva App RCT (2024)

Digital gut-directed hypnotherapy trial

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5yr
Durability
Calvert et al. (2002)

Long-term follow-up Manchester clinic

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204
Patients Treated
Gonsalkorale et al. (2003)

Large-scale clinical outcome data

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Functional GI Disorders

8 studies

Beyond IBS: dyspepsia, GERD, nausea

73%
Dyspepsia Relief
Calvert et al. (2002)

Functional dyspepsia treatment

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↑
Faster Emptying
Nature Review (2006)

Improves gastric emptying

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100
Children Studied
Browne et al. (2019)

Pediatric chronic nausea treatment

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+78d
Remission Extended
Keefer et al. (2013)

Ulcerative colitis adjunct therapy

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40%
GERD Improvement
Miller et al. (2015)

Reflux symptom reduction

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85%
Children Response
Vlieger et al. (2007)

Pediatric functional abdominal pain

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5yr
Pediatric Follow-up
Rutten et al. (2013)

Long-term benefits in children

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Review
Mechanism
Whorwell (2006)

How gut hypnotherapy works - Lancet

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Brain-Gut Science

5 studies

The neuroscience behind gut-directed hypnotherapy

Review
Gut-Brain Axis
Mayer et al. (2015)

UCLA brain-gut interaction research

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AGA
Guidelines
Keefer & Palsson (2016)

American Gastroenterological Association review

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fMRI
Brain Changes
Enck et al. (2017)

Neuroimaging shows brain activity changes

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Imaging
Neural Pathways
Lowen et al. (2013)

IBS brain response normalization

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PET
Serotonin
Tillisch et al. (2011)

Gut serotonin receptor changes

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